Dynamic Aspects Of Platelet Adhesion Under Flow
نویسندگان
چکیده
منابع مشابه
High-speed platelet adhesion under conditions of rapid flow.
The recognition of exposed collagen by circulating platelets is an initial step in the formation of the hemostatic plug or a thrombus after vascular injury. Theoretical calculations of the speed of platelet function required for effective hemostasis have suggested very short reaction times. However, it is not known how fast platelets can adhere to collagen under arterial flow conditions or whic...
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Recent studies have revealed that the platelet adhesive process under flow is tightly regulated by multiple ligand-receptor interactions. However, platelet morphological changes during this process, particularly its physiological relevance, remain unknown under blood flow conditions. Using epifluorescence and scanning electron microscopy, we evaluated the real-time changes in platelet morpholog...
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Collagen type IV is a sheet-forming collagen and a major constituent of the vessel wall. To find out which conditions are important for platelet adhesion to collagen type IV, we performed perfusion studies with anticoagulated blood in parallel plate perfusion chambers. The role of divalent cations was investigated by using plasmas with variable concentrations of Mg2+ and Ca2+ ions. When Mg2+ co...
متن کاملEndothelial C-reactive protein increases platelet adhesion under flow conditions.
While data regarding the pathogenetic role of C-reactive protein (CRP) in atherothrombosis are accumulating, it is still controversial whether local CRP secretion is of any pathobiological significance. The present study examined whether endothelial-derived CRP modulates autocrine prothrombotic activity. Endothelial cells were isolated from hearts of mice transgenic to human CRP and grown in pr...
متن کاملPlatelet Adhesion to Collagen and Collagen-Related Peptide Under Flow
Objective—Platelet stimulation by collagen and collagen-related peptides (CRPs) is associated with activation of protein tyrosine kinases. In the present study, we investigated the role of Src family tyrosine kinases in the initial adhesion events of human platelets to collagen and cross-linked CRP. Methods and Results—Under arterial flow conditions, a glycoprotein VI–specific substrate, cross-...
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ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology and Physiology
سال: 2001
ISSN: 0305-1870,1440-1681
DOI: 10.1046/j.1440-1681.2001.03468.x